A standardised system for rating the certainty of evidence and strength of clinical recommendations.
GRADE (Grading of Recommendations Assessment, Development and Evaluation) is a framework used to rate the certainty (quality) of a body of evidence — typically as high, moderate, low, or very low — based on factors like risk of bias, imprecision, inconsistency, indirectness, and publication bias. It is also used to grade the strength of resulting clinical recommendations as strong or weak/conditional, helping clinicians judge how much confidence to place in a guideline's conclusions. It is widely adopted across systematic reviews and guideline panels, though its application involves subjective judgement calls that can vary between assessors.
This guide was auto-drafted and is pending editorial review.