External ValidationResearch

Testing whether a study's findings hold up in different people, places, or settings.

External validation refers to evaluating a prediction model, diagnostic tool, or research finding using a dataset or population separate from the one it was developed on — assessing whether results generalise beyond the original study sample. This differs from internal validation (e.g. cross-validation or bootstrapping within the same dataset), which checks reproducibility but not generalisability. A model can perform well internally yet fail external validation if the new population differs in demographics, setting, or measurement methods, so clinicians should weigh how similar their own patients are to the validation cohort before applying the tool.

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This guide was auto-drafted and is pending editorial review.