Critical appraisal tool rating the methodological quality of systematic reviews.
AMSTAR 2 is a 16-item checklist used to grade the rigor of a systematic review's methods (e.g. protocol registration, search comprehensiveness, risk-of-bias assessment), yielding an overall confidence rating from high to critically low. A review rated 'critically low' should be interpreted cautiously even when its pooled effect looks favourable.
This guide was auto-drafted and is pending editorial review.